may new biomarkers help us to predict progressive multifocal leukoencephalopathy in hiv positive people?

May New Biomarkers Help us to Predict Progressive Multifocal Leukoencephalopathy in HIV Positive People?

Dear Editor, Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the brain caused by the JC virus (JCV). PML is caused by lytic infection of glial cells in severely immunosuppressed patients and is often fatal. JCV infects most people in childhood and is usually asymptomatic. Afterwards, the virus persists in the body in a latent state, where viral protein expression ...

Progressive multifocal leukoencephalopathy in non-HIV patient

Polyomavirus-Associated Progressive Multifocal Leukoencephalopathy (PML) in HAART era

Polyomaviruses may cause human disease, particularly in immunocompromised hosts. JCV, one of the members of polyomaviridae family, is the causative agent of the neurological disease progressive multifocal leukoencephalopathy (PML), which occurs mostly in immunocompromised patients. Progressive Multifocal leukoencephalopathy (PML) is a progressive demyelinating disorder of the central nervous sy...

Does contrast enhancement predict survival in progressive multifocal leukoencephalopathy?

1. Parsons HF. The influenza epidemics of 1889 –90 and 1891, and their distribution in England and Wales. Brit Med J 1891; 2:303– 8. 2. Taubenberger JK, Morens DM. 1918 influenza: the mother of all pandemics. Emerg Infect Dis 2006; 12:15–22. 3. Yu H, Gao Z, Feng Z, et al. Clinical characteristics of 26 human cases of highly pathogenic avian influenza A (H5N1) virus infection in China. PLoS ONE ...

Progressive Multifocal Leukoencephalopathy

Before embarking on experimental therapies for progressive multifocal leukoencephalopathy (PML), the diagnosis needs to be unequivocally established. Improving the underlying immunodeficiency state is the best initial approach to the management of PML. Immunosuppressive therapies should be discontinued when feasible. In the patient with AIDS, highly active antiretroviral therapy should be admin...

Progressive Multifocal Leukoencephalopathy.

Progressive multifocal leukoencephalopathy is a subacute demyelinating disease that occurs in patients with defects in cell-mediated immunity, including those with AIDS and lymphoproliferative disorders. It is caused by reactivation of JC virus (JCV), which infects 70% to 90% of the population by adulthood, but remains latent in normal hosts. Once reactivated, JCV infects oligodendrocytes and a...